Protective effects of Althaea officinalis L. extract in 6-hydroxydopamine-induced hemi-Parkinsonism model: behavioral, biochemical and histochemical evidence

The Flavonoid Hesperetin Alleviates Behavioral Abnormality in 6-Hydroxydopamine Rat Model of Hemi-Parkinsonism

ABSTRACTParkinson’s disease (PD) is a neuropathological and debilitating disorder involving the degeneration of mesencephalic dopaminergic neurons. Neuroprotective effect of hesperetin has already been reported, therefore, this study examined whether the administration of this flavonoid would attenuate behavioral abnormalities in an experimental model of PD in rat. For this purpose, unilateral ...

Evaluation of Betaine Neuroprotective Effects on 6-Hydroxydopamine-Induced hemi-Parkinsonism in Male Wistar Rats

BACKGROUND: Parkinson's disease (PD) is one of the prevalent debilitating neurodegenerative disor- ders. Accordingly, researchers are working on methods to modify PD progression. Previously, the neuro- protective effects of betaine, as a methyl donor agent in homocysteine metabolism, have been demonstrated in animal models of chronic cerebral hypoperfusion and memory deficits. OBJECTIVES: It wa...

the flavonoid hesperetin alleviates behavioral abnormality in 6-hydroxydopamine rat model of hemi-parkinsonism

abstractparkinson’s disease (pd) is a neuropathological and debilitating disorder involving the degeneration of mesencephalic dopaminergic neurons. neuroprotective effect of hesperetin has already been reported, therefore, this study examined whether the administration of this flavonoid would attenuate behavioral abnormalities in an experimental model of pd in rat. for this purpose, unilateral ...

Melissa officinalis aqueous extract ameliorates 6-hydroxydopamine-induced neurotoxicity in hemi-parkinsonian rat

ABSTRACT Background and Objective: Parkinson's disease (PD) is an age-related neurodegenerative disorder with massive loss of dopaminergic neurons in the substantia nigra pars compacta. L-Dihydroxyphenylalanine (L-DOPA) substitution is still the gold standard therapy for PD. However, there has been little information available on neuroprotective and regenerative therapies for PD. Due to the neu...

The Flavonoid Hesperetin Alleviates Behavioral Abnormality in 6-Hydroxydopamine Rat Model of Hemi-Parkinsonism